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1

Deciphering the Structural Basis of Eukaryotic Protein Kinase Regulation

Meharena, Hiruy S., Chang, Philip, Keshwani, Malik M., Oruganty, Krishnadev, Nene, Aishwarya K., Kannan, Natarajan, Taylor, Susan S., Kornev, Alexandr P., Petsko, Gregory A.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.23 MB

english, 2013

2

Protein kinases: evolution of dynamic regulatory proteins

Susan S. Taylor, Alexandr P. Kornev

Journal:

Trends in Biochemical Sciences

Year:

2011

Language:

english

File:

PDF, 1.09 MB

english, 2011

3

Assembly of allosteric macromolecular switches: lessons from PKA

Taylor, Susan S., Ilouz, Ronit, Zhang, Ping, Kornev, Alexandr P.

Journal:

Nature Reviews Molecular Cell Biology

Year:

2012

Language:

english

File:

PDF, 1.97 MB

english, 2012

4

Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers

Hu, Jiancheng, Stites, Edward C., Yu, Haiyang, Germino, Elizabeth A., Meharena, Hiruy S., Stork, Philip J.S., Kornev, Alexandr P., Taylor, Susan S., Shaw, Andrey S.

Journal:

Year:

2013

Language:

english

File:

PDF, 2.17 MB

english, 2013

5

Free Malcev algebra of rank three

Kornev, Alexandr I.

Journal:

Journal of Algebra

Year:

2014

Language:

english

File:

PDF, 351 KB

english, 2014

6

Conserved spatial patterns across the protein kinase family

Lynn F. Ten Eyck, Susan S. Taylor, Alexandr P. Kornev

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2008

Language:

english

File:

PDF, 790 KB

english, 2008

7

Defining the conserved internal architecture of a protein kinase

Alexandr P. Kornev, Susan S. Taylor

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2010

Language:

english

File:

PDF, 773 KB

english, 2010

8

PKA: assembly of dynamic macromolecular signaling

Susan S Taylor, Ronit Ilouz, Manjula Darshi, Ganapathy Sarma, Alexandr Kornev, Ping Zhang

Journal:

BMC Pharmacology

Year:

2011

Language:

english

File:

PDF, 128 KB

english, 2011

9

A chimeric mechanism for polyvalent trans-phosphorylation of PKA by PDK1

Robert A. Romano, Natarajan Kannan, Alexandr P. Kornev, Craig J. Allison, Susan S. Taylor

Journal:

Protein Science

Year:

2009

Language:

english

File:

PDF, 1.45 MB

english, 2009

10

Comparative surface geometry of the protein kinase family

Elaine E. Thompson, Alexandr P. Kornev, Natarajan Kannan, Choel Kim, Lynn F. Ten Eyck, Susan S. Taylor

Journal:

Protein Science

Year:

2009

Language:

english

File:

PDF, 933 KB

english, 2009

11

Dissecting the cAMP-inducible allosteric switch in protein kinase A RIα

Timothy J. Sjoberg, Alexandr P. Kornev, Susan S. Taylor

Journal:

Protein Science

Year:

2010

Language:

english

File:

PDF, 402 KB

english, 2010

12

Dynamics connect substrate recognition to catalysis in protein kinase A

Masterson, Larry R, Cheng, Cecilia, Yu, Tao, Tonelli, Marco, Kornev, Alexandr, Taylor, Susan S, Veglia, Gianluigi

Journal:

Nature Chemical Biology

Year:

2010

Language:

english

File:

PDF, 1.72 MB

english, 2010

13

Dynamics connect substrate recognition to catalysis in protein kinase A

Masterson, Larry R, Cheng, Cecilia, Yu, Tao, Tonelli, Marco, Kornev, Alexandr, Taylor, Susan S, Veglia, Gianluigi

Journal:

Nature Chemical Biology

Year:

2011

File:

PDF, 54 KB

2011

14

Pseudokinases: Functional Insights Gleaned from Structure

Alexandr P. Kornev, Susan S. Taylor

Journal:

Year:

2009

Language:

english

File:

PDF, 513 KB

english, 2009

15

Realizing the Allosteric Potential of the Tetrameric Protein Kinase A RIα Holoenzyme

Angela J. Boettcher, Jian Wu, Choel Kim, Jie Yang, Jessica Bruystens, Nikki Cheung, Juniper K. Pennypacker, Donald A. Blumenthal, Alexandr P. Kornev, Susan S. Taylor

Journal:

Year:

2011

Language:

english

File:

PDF, 2.28 MB

english, 2011

16

Crystal Structure of cGMP-Dependent Protein Kinase Reveals Novel Site of Interchain Communication

Brent W. Osborne, Jian Wu, Caitlin J. McFarland, Christian K. Nickl, Banumathi Sankaran, Darren E. Casteel, Virgil L. Woods Jr., Alexandr P. Kornev, Susan S. Taylor, Wolfgang R. Dostmann

Journal:

Year:

2011

Language:

english

File:

PDF, 1.40 MB

english, 2011

17

A Conserved Glu–Arg Salt Bridge Connects Coevolved Motifs That Define the Eukaryotic Protein Kinase Fold

Jie Yang, Jian Wu, Jon M. Steichen, Alexandr P. Kornev, Michael S. Deal, Sheng Li, Banumathi Sankaran, Virgil L. Woods Jr., Susan S. Taylor

Journal:

Journal of Molecular Biology

Year:

2012

Language:

english

File:

PDF, 1.55 MB

english, 2012

18

PKA: Lessons learned after twenty years

Taylor, Susan S., Zhang, Ping, Steichen, Jon M., Keshwani, Malik M., Kornev, Alexandr P.

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2013

Language:

english

File:

PDF, 1.45 MB

english, 2013

19

PKA RIα Homodimer Structure Reveals an Intermolecular Interface with Implications for Cooperative cAMP Binding and Carney Complex Disease

Bruystens, Jessica G.H., Wu, Jian, Fortezzo, Audrey, Kornev, Alexandr P., Blumenthal, Donald K., Taylor, Susan S.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.95 MB

english, 2014

20

Kinase Regulation by Hydrophobic Spine Assembly in Cancer

Hu, Jiancheng, Ahuja, Lalima G., Meharena, Hiruy S., Kannan, Natarajan, Kornev, Alexandr P., Taylor, Susan S., Shaw, Andrey S.

Journal:

Molecular and Cellular Biology

Year:

2015

Language:

english

File:

PDF, 4.03 MB

english, 2015

21

Using Markov State Models to Develop a Mechanistic Understanding of Protein Kinase A Regulatory Subunit RIα Activation in Response to cAMP Binding

Boras, Britton W., Kornev, Alexandr, Taylor, Susan S., McCulloch, Andrew D.

Journal:

Journal of Biological Chemistry

Year:

2014

Language:

english

File:

PDF, 4.09 MB

english, 2014

22

Yet another "active" pseudokinase, Erb3

Susan S. Taylor and Alexandr P. Kornev

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 604 KB

english, 2010

23

Discovery of allostery in PKA signaling

Zhang, Ping, Kornev, Alexandr P., Wu, Jian, Taylor, Susan S.

Journal:

Biophysical Reviews

Year:

2015

Language:

english

File:

PDF, 1.86 MB

english, 2015

24

A Generalized Allosteric Mechanism for cis-Regulated Cyclic Nucleotide Binding Domains

Kornev, Alexandr P., Taylor, Susan S., Ten Eyck, Lynn F., Ranganathan, Rama

Journal:

PLoS Computational Biology

Year:

2008

Language:

english

File:

PDF, 619 KB

english, 2008

25

Allostery through the computational microscope: cAMP activation of a canonical signalling domain

Malmstrom, Robert D., Kornev, Alexandr P., Taylor, Susan S., Amaro, Rommie E.

Journal:

Nature Communications

Year:

2015

Language:

english

File:

PDF, 2.67 MB

english, 2015

26

Integration of signaling in the kinome: Architecture and regulation of the αC Helix

Taylor, Susan S., Shaw, Andrey S., Kannan, Natarajan, Kornev, Alexandr P.

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2015

Language:

english

File:

PDF, 1.77 MB

english, 2015

27

An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes

Zhang, Ping, Ye, Feng, Bastidas, Adam C., Kornev, Alexandr P., Wu, Jian, Ginsberg, Mark H., Taylor, Susan S.

Journal:

Year:

2015

Language:

english

File:

PDF, 2.74 MB

english, 2015

28

Dynamics-Driven Allostery in Protein Kinases

Kornev, Alexandr P., Taylor, Susan S.

Journal:

Trends in Biochemical Sciences

Year:

2015

Language:

english

File:

PDF, 4.74 MB

english, 2015

29

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF

Jiancheng Hu, Haiyang Yu, Alexandr P. Kornev, Jianping Zhao, Erin L. Filbert, Susan S. Taylor and Andrey S. Shaw

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 1.48 MB

english, 2011

30

Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII

Antal, Corina E., Callender, Julia A., Kornev, Alexandr P., Taylor, Susan S., Newton, Alexandra C.

Journal:

Year:

2015

Language:

english

File:

PDF, 2.29 MB

english, 2015

31

Hydrogen reduction of98MoF6in RF discharge

Kornev, Roman A., Sennikov, Petr G., Konychev, Dmitry A., Potapov, Alexandr M., Chuvilin, Dmitry Yu., Yunin, Pavel A., Gusev, Sergey A., Naumann, Martin

Journal:

Journal of Radioanalytical and Nuclear Chemistry

Year:

2016

Language:

english

File:

PDF, 1.38 MB

english, 2016

32

Protein-Ligand Interactions through the Computational Microscope: Allostery in a Canonical Signaling Domain

Malmstrom, Robert D., Kornev, Alexandr P., Taylor, Susan S., Amaro, Rommie E.

Journal:

Biophysical Journal

Year:

2016

Language:

english

File:

PDF, 38 KB

english, 2016

33

Pseudokinases from a structural perspective

Taylor, Susan S., Shaw, Andrey, Hu, Jiancheng, Meharena, Hiruy S., Kornev, Alexandr

Journal:

Biochemical Society Transactions

Year:

2013

Language:

english

File:

PDF, 404 KB

english, 2013

34

The evolution of protein phosphorylation || Evolution of the eukaryotic protein kinases as dynamic molecular switches

Susan S. Taylor, Malik M. Keshwani, Jon M. Steichen and Alexandr P. Kornev

Journal:

Philosophical Transactions Biological Sciences

Year:

2012

Language:

english

File:

PDF, 3.07 MB

english, 2012

35

Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer

Ahuja, Lalima G., Kornev, Alexandr P., McClendon, Christopher L., Veglia, Gianluigi, Taylor, Susan S.

Journal:

Proceedings of the National Academy of Sciences

Year:

2017

Language:

english

File:

PDF, 2.23 MB

english, 2017

36

Fractal Nature of Protein Interior and its Implications for Protein Function

Kornev, Alexandr P., Taylor, Susan S.

Journal:

Biophysical Journal

Year:

2017

Language:

english

File:

PDF, 57 KB

english, 2017

37

Electrostatic Interactions as Mediators in the Allosteric Activation of Protein Kinase A RIα

P. Barros, Emília, Malmstrom, Robert D., Nourbakhsh, Kimya, Del Rio, Jason C., Kornev, Alexandr P., Taylor, Susan S., Amaro, Rommie E.

Journal:

Year:

2017

Language:

english

File:

PDF, 23.72 MB

english, 2017

38

A dynamic hydrophobic core orchestrates allostery in protein kinases

Kim, Jonggul, Ahuja, Lalima G., Chao, Fa-An, Xia, Youlin, McClendon, Christopher L., Kornev, Alexandr P., Taylor, Susan S., Veglia, Gianluigi

Journal:

Science Advances

Year:

2017

Language:

english

File:

PDF, 4.60 MB

english, 2017

39

Divalent metal ions control activity and inhibition of protein kinases

Knape, Matthias J., Ballez, Mike, Burghardt, Nicole C., Zimmermann, Bastian, Bertinetti, Daniela, Kornev, Alexandr P., Herberg, Friedrich W.

Journal:

Year:

2017

Language:

english

File:

PDF, 2.21 MB

english, 2017

40

A Catalytically-Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation

Meng, Yilin, Ahuja, Lalima G., Kornev, Alexandr P., Taylor, Susan S., Roux, Benoît

Journal:

Journal of Molecular Biology

Year:

2018

Language:

english

File:

PDF, 1.13 MB

english, 2018

41

Self-organization, entropy and allostery

Kornev, Alexandr P.

Journal:

Biochemical Society Transactions

Year:

2018

Language:

english

File:

PDF, 1.67 MB

english, 2018

42

An Allosteric Region of Src Tyrosine Kinase Allows for Stabilization of Its Active-Like Conformation

Ahuja, Lalima G., Meng, Yilin, Kornev, Alexandr P., Roux, Benoit, Taylor, Susan

Journal:

Biophysical Journal

Year:

2018

Language:

english

File:

PDF, 42 KB

english, 2018

43

Corrigendum to “A Catalytically-Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation.” J. Mol. Biol. 430(6) (Mar 16 2018), 881–889

Meng, Yilin, Ahuja, Lalima G., Kornev, Alexandr P., Taylor, Susan S., Roux, Benoît

Journal:

Journal of Molecular Biology

Year:

2018

Language:

english

File:

PDF, 128 KB

english, 2018

44

Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores

Gógl, Gergő, Kornev, Alexandr P., Reményi, Attila, Taylor, Susan S.

Journal:

Trends in Biochemical Sciences

Year:

2019

Language:

english

File:

PDF, 3.47 MB

english, 2019

45

The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain

Schmidt, Sven H., Knape, Matthias J., Boassa, Daniela, Mumdey, Natascha, Kornev, Alexandr P., Ellisman, Mark H., Taylor, Susan S., Herberg, Friedrich W.

Journal:

Proceedings of the National Academy of Sciences

Year:

2019

Language:

english

File:

PDF, 1.61 MB

english, 2019

46

Impaired Autoinhibition of Protein Kinase CÎ³ in Spinocerebellar Ataxia Type 14

Pilo, Caila A., Kunkel, Maya T., Van, An-Angela N., Kobori, Evan K., Kornev, Alexandr P., Longman, Cheryl, Gorrie, George, Taylor, Susan S., Newton, Alexandra C.

Journal:

Biophysical Journal

Year:

2020

File:

PDF, 47 KB

2020

47

Allostery Explained Through Synchronized Oscillators and Fractal Networks

Kornev, Alexandr P.

Journal:

Biophysical Journal

Year:

2020

File:

PDF, 40 KB

2020

48

Hypothesis: Unifying model of domain architecture for conventional and novel protein kinase C isozymes

Jones, Alexander C., Taylor, Susan S., Newton, Alexandra C., Kornev, Alexandr P.

Journal:

Year:

2020

File:

PDF, 2.64 MB

2020

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